Journal of Cardiothoracic and Vascular Anesthesia
Volume 17, Issue 1 , Pages 1-3 , February 2003

S100β and NSE: Stroke surrogate signals or natal neural noise?

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  1. Nishiyama H, Knopfel T, Endo S, Itohara S. Glial protein S100β modulates long-term neuronal synaptic plasticity. Proc Natl Acad Sci. 2002;19:4037–4042
  2. Missler U, Wiesman M, Friedrich C, Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke. 1997;28:1956–1960
  3. Blennow M, Savman K, Ilves P, et al.  Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants. Acta Paediatr. 2001;90:1171–1175
  4. Grocott HP, Croughwell ND, Amory DW, et al.  Cerebral emboli and serum S100β during cardiac operations. Ann Thorac Surg. 1998;65:1645–1650
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  6. Diegeler A, Hirsch R, Schneider F, et al.  Neuromonitoring and neurocognitive outcome in off-pump versus conventional coronary bypass operation. Ann Thorac Surg. 2000;69:1162–1166
  7. Usui A, Kato K, Murase M, et al.  Neural tissue-related proteins (NSE, GO alpha, 28-kDa calbindin-D, S100β and CK-BB) in serum and cerebrospinal fluid after cardiac arrest. J Neurol Sci. 1994;123:134–139
  8. Westaby S, Johnson P, Parry AJ, et al.  Serum S100 protein: A potential marker for cerebral events during cardiopulmonary bypass. Ann Thorac Surg. 1996;61:88–92
  9. Potapov EV, Loebe M, Abdul-Khaliq H, et al.  Postoperative course of S-100β protein and neuron-specific enolase in patients after implantation of continuous and pulsatile flow LVADs. J Heart Lung Transplant. 2001;20:1116–1310
  10. Jonsson H, Johnsson P, Allig C, et al.  Significance of serum S100 release after coronary artery bypass grafting. Ann Thorac Surg. 1998;65:1639–1644
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  12. Derkach DN, Okamoto H, Takahashi S. Neuronal and astroglial injuries in patients undergoing coronary artery bypass grafting and aortic arch replacement during hypothermic cardiopulmonary bypass. Anesth Analg. 2000;91:1066–1072
  13. Svenmarker S, Sandstrom E, Karlsson T, et al.  Is there an association between release of protein S100β during cardiopulmonary bypass and memory disturbances?. Scand Cardiovasc J. 2002;36:117–122
  14. Vaage J, Anderson R. Biochemical markers of neurologic injury in cardiac surgery: the rise and fall of S100β. J Thorac Cardiovasc Surg. 2001;122:1019–1020
  15. Jackson RG, Sales KM, Samra GS, Strunin L. Extracranial sources of S100β. Br J Anaesth. 2001;86:601
  16. Babin-Ebell J, Misoph M, Mullges W, et al.  Intraoperative embolus formation during cardiopulmonary bypass affects the release of S100β. J Thorac Cardiovasc Surg. 1999;47:166–169
  17. Rimpilainen J, Pokela M, Kiviluoma K, et al.  Leukocyte filtration improves brain protection after a prolonged period of hypothermic circulatory arrest: A study in a chronic porcine model. J Thorac Cardiovasc Surg. 2000;120:1131–1141
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PII: S1053-0770(02)47701-4

doi: 10.1053/jcan.2003.1

Journal of Cardiothoracic and Vascular Anesthesia
Volume 17, Issue 1 , Pages 1-3 , February 2003