Journal of Cardiothoracic and Vascular Anesthesia
Volume 17, Issue 1 , Pages 4-9 , February 2003

Are serum S100β proteins and neuron-specific enolase predictors of cerebral damage in cardiovascular surgery?

References 

  1. Roach GW, Kanchuger M, Mangano CM, et al.  Adverse cerebral outcomes after coronary bypass surgery. N Engl J Med. 1996;335:1857–1863
  2. McKhann GM, Goldsborough MA, Borowicz LM, et al.  Predictors of stroke risk in coronary artery bypass patients. Ann Thorac Surg. 1997;63:516–521
  3. Persson L, Hårdemark H, Gustafsson J, et al.  S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: Markers of cell damage in human central nervous system. Stroke. 1987;18:911–918
  4. Missler U, Wiesmann M, Friedrich C, Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke. 1997;28:1956–1960
  5. Persson L, Hårdemark H, Edner G, et al.  S-100 protein in cerebrospinal fluid of patients with subarachnoid haemorrhage: A potential marker of brain damage. Acta Neurochir. 1988;93:116–122
  6. Romner B, Ingebrigtsen T, Kongstad P, Borgesen SE. Traumatic brain damage: Serum S-100 protein measurements related to neuroradiological findings. J Neurotrauma. 2000;17:641–647
  7. Usui A, Kato K, Murase M, et al.  Neural tissue-related proteins (NSE, G0α, 28- kDa calbindin-D, S100β and CK-BB) in serum and cerebrospinal fluid after cardiac arrest. J Neurol Sci. 1994;123:134–139
  8. Gao F, Harris DNF, Sapsed-Byrne S. Time course of neuron-specific enolase and S-100 protein release during and after coronary artery bypass grafting. Br J Anaesth. 1999;82:266–267
  9. Ali MS, Harmer M, Vaughan R. Serum S100 protein as a marker of cerebral damage during cardiac surgery. Br J Anaesth. 2000;85:287–298
  10. Johnsson P, Lundqvist C, Lindgren A, et al.  Cerebral complications after cardiac surgery assessed by S-100 and NSE levels in blood. J Cardiothrac Vasc Anesth. 1995;9:694–699
  11. Westaby S, Johnsson P, Parry AJ, et al.  Serum S100 protein: A potential marker for cerebral events during cardiopulmonary bypass. Ann Thorac Surg. 1996;61:88–92
  12. Blomquist S, Johnsson P, Lührs C, et al.  The appearance of S-100 protein in serum during and immediately after cardiopulmonary bypass surgery: A possible marker for cerebral injury. J Cardiothrac Vasc Anesth. 1997;11:699–703
  13. Jönsson H, Johnsson P, Alling C, et al.  Significance of serum S100 release after coronary artery bypass grafting. Ann Thorac Surg. 1998;65:1639–1644
  14. Grocott HP, Croughwell ND, Amory DW, et al.  Cerebral emboli and serum S100β during cardiac operations. Ann Thorac Surg. 1998;65:1645–1650
  15. Derkach DN, Okamoto H, Takahashi S. Neuronal and astroglial injuries in patients undergoing coronary artery bypass grafting and aortic arch replacement during hypothermic cardiopulmonary Bypass. Anesth Analg. 2000;91:1066–1072
  16. Hayashi J, Eguchi S, Yasuda K, et al.  Aortic arch operation using selective cerebral perfusion for nondissecting thoracic aneurysm. Ann Thorac Surg. 1997;63:88–92
  17. Anderson RE, Hansson LO, Liska J, et al.  The effect of cardiotomy suction on the brain injury marker S100β after cardiopulmonary bypass. Ann Thorac Surg. 2000;69:847–850
  18. Gao F, Harris DNF, Sapsed-Byrne S. Neuron-specific enolase and Sangtec 100 assays during cardiac surgery: part III-does haemolysis affect their accuracy?. Perfusion. 1997;12:171–177
  19. Arrowsmith JE, Grocott HP, Newman MF. Neurologic risk assessment, monitoring and outcome in cardiac surgery. J Cardiothrac Vasc Anesth. 1999;13:736–743
  20. Anderson RE, Hansson L, Vaage J. Release of S100B during coronary artery bypass grafting is reduced by off-pump surgery. Ann Thorac Surg. 1999;67:1721–1725
  21. Diegeler A, Hirsch R, Schneider F, et al.  Neuromonitoring and neurocognitive outcome in off-pump versus conventional coronary bypass operation. Ann Thorac Surg. 2000;69:1162–1166
  22. Kato K, Ishiguro Y, Suzuki F, et al.  Distribution of nervous system- specific forms of enolase in peripheral tissues. Brain Res. 1982;237:441–448
  23. Haimoto H, Takahashi Y, Koshikawa T, et al.  Immunohistochemical localization of γ-enolase in normal human tissues other than nervous and neuroendocrine tissues. Lav Invest. 1985;52:257–263
  24. Marangos PJ, Campbell IC, Schmechel DE, et al.  Blood platelets contain a neuron-specific enolase subunit. J Neurochem. 1980;34:1254–1258
  25. Hidaka H, Endo T, Kawamoto S, et al.  Purification and characterization of adipose tissue S-100β protein. J Biol Chem. 1983;258:2705–2709
  26. Kojima K, Wekerle H, Lassmann H, et al.  Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, S-100β. J Neural Transm. 1997;49:S43–S51
  27. Martin R, McKenty S, Thisdale Y, et al.  Hemolysis during cardiopulmonary bypass. J Cardiothrac Vasc Anesth. 1989;3:737–740

☆ Supported in part by the Young Researcher Project of the Venture business Laboratory, Yamaguchi University and in part by the Ministry of Education, Science, Sports and Culture (Grant No 12671474. to Kazuyoshi Ishida).

☆☆ Address reprint requests to Kazuyoshi Ishida, MD, Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. E-mail: kazuyo@yamaguchi-u.ac.jp.

PII: S1053-0770(02)47702-6

doi: 10.1053/jcan.2003.2

Journal of Cardiothoracic and Vascular Anesthesia
Volume 17, Issue 1 , Pages 4-9 , February 2003

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