Journal of Cardiothoracic and Vascular Anesthesia
Volume 20, Issue 2 , Pages 167-172 , April 2006

Impact of Vasopressin on Hemodynamic and Metabolic Function in the Decompensatory Phase of Hemorrhagic Shock

  • Ken B. Johnson, MD

      Affiliations

    • Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, UT
    • Corresponding Author InformationAddress reprint requests to Ken B. Johnson, MD, Department of Anesthesiology, University of Utah School of Medicine, 30 North, 1900 East, Room 3C444, Salt Lake City, UT 84132-2304
    • ,
  • Frederick J. Pearce, PhD

      Affiliations

    • Department of Resuscitative Medicine, Walter Reed Army Institute of Research, Silver Spring, MD
    • ,
  • Nicole Jeffreys, MD

      Affiliations

    • University of Michigan Hospitals and Health Centers, Ann Arbor, MI
    • ,
  • Scott W. McJames, MS

      Affiliations

    • Department of Resuscitative Medicine, Walter Reed Army Institute of Research, Silver Spring, MD
    • ,
  • Mark Cluff, BS

      Affiliations

    • Department of Resuscitative Medicine, Walter Reed Army Institute of Research, Silver Spring, MD

References 

  1. Stadlbauer KH , Wagner-Berger HG , Raedler C , et al.   Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs . Anesthesiology . 2003;98:699–704
  2. Voelckel WG , Lurie KG , Lindner KH , et al.   Vasopressin improves survival after cardiac arrest in hypovolemic shock . Anesth Analg . 2000;91:627–634
  3. Voelckel WG , Raedler C , Wenzel V , et al.   Arginine vasopressin, but not epinephrine, improves survival in uncontrolled hemorrhagic shock after liver trauma in pigs . Crit Care Med . 2003;31:1160–1165
  4. Wang B , Flora-Ginter G , Leadley RJ . Ventricular receptors stimulate vasopressin release during hemorrahge . Am J Physiol . 1988;254:R204–R211
  5. Morales D , Madigan J , Cullinane S , et al.   Reversal by vasopressin of intractable hypotension in the late phase of hemorrhagic shock . Circulation . 1999;100:226–229
  6. Arnauld E , Czernichow P , Fumoux F . The effects of hypotension and hypovolaemia on the liberation of vasopressin during hemorrhage in the unanaesthetized monkey (Macaca Mulatta) . Pflugers Arch Eur J Physiol . 1977;371:193–200
  7. Kusano E , Tian S , Umino T , et al.   Arginine vasopressin inhibits interleukin-1 beta-stimulated nitric oxide and cyclic guanosine monophosphate production via the V1 receptor in cultured rat vascular smooth muscle cells . J Hypertens . 1997;15:627–632
  8. Umino T , Kusano E , Muto S , et al.   AVP inhibits LPS- and IL-1beta-stimulated NO and cGMP via V1 receptor in cultured rat mesangial cells . Am J Physiol . 1999;276:F433–F441
  9. Moreau R , Barriere E , Tazi KA , et al.   Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis . Hepatology . 2002;36:1070–1078
  10. Bucher M , Hobbhahn J , Taeger K , et al.   Cytokine-mediated downregulation of vasopressin V1a receptors during acute endotoxemia in rats . Am J Physiol Regul Integr Comp Physiol . 2002;282:R979–R984
  11. Holmes CI , Patel BM , Russell JA , et al.   Physiology of vasopressin relevant to management of septic shock . Chest . 2001;120:989–1002
  12. Chu CJ , Wu SL , Lee FY , et al.   Splanchnic hyposensitivity to glypressin in a haemorrhage/transfused rat model of portal hypertension (Role of nitric oxide and bradykinin) . Clin Sci (Lond) . 2000;99:475–482
  13. Ko J , Williams B , Smith V , et al.   Comparison of telazol-ketamine, telazol-xylazine, and telazol-ketamine-xylazine as chemical restraint and anesthetic induction combination in swine . Lab Anim Sci . 1993;43:476–480
  14. Lundeen G , Manohar M , Parks C . Systemic distribution of blood flow in swine while awake and during 1.0 and 1.5 MAC isoflurane anesthesia with or without 50% nitrous oxide . Anesth Analg . 1983;62:499–512
  15. Holt J , Rhode E , Kines H . Ventricular volumes and body weight in mammals . Am J Physiol . 1968;215:704–715
  16. Wiggers CJ . In: Physiology of Shock . New York: Oxford University Press; 1950;p. 121–146
  17. Machin D , Campbell MJ . Statistical Tables for the Design of Clinical Trials . Oxford: Blackwell Scientific Publications; 1987;
  18. Voelckel WG , Lurie KG , McKnite S , et al.   Comparison of epinephrine with vasopressin on bone marrow blood flow in an animal model of hypovolemic shock and subsequent cardiac arrest . Crit Care Med . 2001;29:1587–1592
  19. Alspaugh DM , Sartorelli K , Shackford SR , et al.   Prehospital resuscitation with phenylephrine in uncontrolled hemorrhagic shock and brain injury . J Trauma . 2000;48:851–863 discussion 863-864
  20. American College of Surgeons Committee on Trauma . Advanced Trauma Life Support Course Handbook . Chicago, IL: American College of Surgeons; 1989;
  21. Bellamy RF , Maningas PA , Wenger BA . Current shock models and clinical correlations . Ann Emerg Med . 1986;15:1392–1395

 Supported in part by a grant from the National Institute of Health, Bethesda, MD (grant no. K08GM00712) and by the Department of Anesthesiology, University of Utah.

PII: S1053-0770(05)00464-7

doi: 10.1053/j.jvca.2005.11.015

Journal of Cardiothoracic and Vascular Anesthesia
Volume 20, Issue 2 , Pages 167-172 , April 2006

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