Journal of Cardiothoracic and Vascular Anesthesia
Volume 21, Issue 4 , Pages 524-528 , August 2007

Kaolin-Based Activated Coagulation Time Measured by Sonoclot in Patients Undergoing Cardiopulmonary Bypass

Presented in part at the annual meeting of the Swiss Society of Anesthesiologists, Fribourg, Switzerland, November 5-6, 2004.

  • Michael T. Ganter, MD, DEAA

      Affiliations

    • Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA
    • Corresponding Author InformationAddress reprint requests to Michael T. Ganter, MD, DEAA, Department of Anesthesia and Perioperative Care, San Francisco General Hospital, UCSF, 1001 Potrero Avenue, Room 3C-38, San Francisco, CA 94110.
    • ,
  • Antoinette Monn, BS

      Affiliations

    • Institute of Hematology and Oncology, Triemli City Hospital, Zurich, Switzerland
    • ,
  • Reza Tavakoli, MD

      Affiliations

    • Division of Cardiac Surgery, Triemli City Hospital, Zurich, Switzerland
    • ,
  • Richard Klaghofer, PhD

      Affiliations

    • Department of Psychosocial Medicine, University Hospital, Zurich, Switzerland.
    • ,
  • Andreas Zollinger, MD

      Affiliations

    • Institute of Anesthesiology and Intensive Care Medicine, Triemli City Hospital, Zurich, Switzerland
    • ,
  • Christoph K. Hofer, MD, DEAA

      Affiliations

    • Institute of Anesthesiology and Intensive Care Medicine, Triemli City Hospital, Zurich, Switzerland

References 

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  5. Dalbert S, Ganter MT, Furrer L, et al. Effects of heparin, haemodilution and aprotinin on kaolin-based activated clotting time: In vitro comparison of two different point of care devices. Acta Anaesthesiol Scand. 2006;50:461–468
  6. Ganter MT, Dalbert S, Graves K, et al. Monitoring activated clotting time for combined heparin and aprotinin application: An in vitro evaluation of a new aprotinin-insensitive test using SONOCLOT. Anesth Analg. 2005;101:308–314
  7. Ganter MT, Monn A, Tavakoli R, et al. Monitoring activated clotting time for combined heparin and aprotinin application: In vivo evaluation of a new aprotinin-insensitive test using Sonoclot. Eur J Cardiothorac Surg. 2006;30:278–284
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  9. Culliford AT, Gitel SN, Starr N, et al. Lack of correlation between activated clotting time and plasma heparin during cardiopulmonary bypass. Ann Surg. 1981;193:105–111
  10. Leyvi G, Shore-Lesserson L, Harrington D, et al. An investigation of a new activated clotting time “MAX-ACT” in patients undergoing extracorporeal circulation. Anesth Analg. 2001;92:578–583
  11. Despotis GJ, Summerfield AL, Joist JH, et al. Comparison of activated coagulation time and whole blood heparin measurements with laboratory plasma anti-Xa heparin concentration in patients having cardiac operations. J Thorac Cardiovasc Surg. 1994;108:1076–1082
  12. Despotis GJ, Filos KS, Levine V, et al. Aprotinin prolongs activated and nonactivated whole blood clotting time and potentiates the effect of heparin in vitro. Anesth Analg. 1996;82:1126–1131
  13. Moorehead MT, Westengard JC, Bull BS. Platelet involvement in the activated coagulation time of heparinized blood. Anesth Analg. 1984;63:394–398
  14. Linden MD, Schneider M, Erber WN. Acute normovolemic hemodilution does not reduce antithrombin concentration for cardiac surgery. J Thromb Thrombolysis. 2004;17:173–176
  15. Despotis GJ, Levine V, Joist JH, et al. Antithrombin III during cardiac surgery: Effect on response of activated clotting time to heparin and relationship to markers of hemostatic activation. Anesth Analg. 1997;85:498–506
  16. Krulder JW, Strebus AF, Meinders AE, et al. Anticoagulant effect of unfractionated heparin in antithrombin-depleted plasma in vitro. Haemostasis. 1996;26:85–89
  17. Henry DA, Moxey AJ, Carless PA, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2001;CD001886
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  23. Dietrich W, Jochum M. Effect of celite and kaolin on activated clotting time in the presence of aprotinin: Activated clotting time is reduced by binding of aprotinin to kaolin. J Thorac Cardiovasc Surg. 1995;109:177–178
  24. Hett DA, Walker D, Pilkington SN, et al. Sonoclot analysis. Br J Anaesth. 1995;75:771–776
  25. Tucci MA, Ganter MT, Hamiel CR, et al. Platelet function monitoring with the Sonoclot analyzer after in vitro tirofiban and heparin administration. J Thorac Cardiovasc Surg. 2006;131:1314–1322

PII: S1053-0770(06)00461-7

doi: 10.1053/j.jvca.2006.12.012

Journal of Cardiothoracic and Vascular Anesthesia
Volume 21, Issue 4 , Pages 524-528 , August 2007

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