Journal of Cardiothoracic and Vascular Anesthesia
Volume 22, Issue 5 , Pages 670-674 , October 2008

Sonoclot Analysis in Coronary Artery Surgery: A Comparison Between Patients With Unstable Coronary Artery Disease Treated With Enoxaparin Before Surgery and Patients With Stable Coronary Artery Disease Not Treated With Enoxaparin

  • Hilde Pleym, MD, PhD

      Affiliations

    • Department of Cardiothoracic Anesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway
    • Corresponding Author InformationAddress reprint requests to Hilde Pleym, MD, PhD, St Elisabeth Department of Cardiothoracic Surgery, Hans Nissens gate 3, N-7018 Trondheim, Norway
    • ,
  • Alexander Wahba, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, St Olav University Hospital, Trondheim, Norway
    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Lise Bjella, MD

      Affiliations

    • Department of Cardiothoracic Anesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway
    • ,
  • Roar Stenseth, MD, PhD

      Affiliations

    • Department of Cardiothoracic Anesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway

References 

  1. Fragmin during Instability in Coronary Artery Disease (FRISC) study group. Low-molecular-weight heparin during instability in coronary artery disease. Lancet. 1996;347:561–568
  2. Cohen M, Demers C, Gurfinkel EP, et al. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. N Engl J Med. 1997;337:447–452
  3. Antman EM, McCabe CH, Gurfinkel EP, et al. Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q-wave myocardial infarction (Results of the thrombolysis in myocardial infarction (TIMI) 11B trial). Circulation. 1999;100:1593–1601
  4. Clark SC, Vitale N, Zacharias J, et al. Effect of low-molecular-weight heparin (Fragmin) on bleeding after cardiac surgery. Ann Thorac Surg. 2000;69:762–765
  5. Kincaid EH, Monroe ML, Saliba DL, et al. Effects of preoperative enoxaparin versus unfractionated heparin on bleeding indices in patients undergoing coronary artery bypass grafting. Ann Thorac Surg. 2003;76:124–128
  6. Jones HU, Muhlestein JB, Jones KW, et al. Preoperative use of enoxaparin compared with unfractionated heparin increases the incidence of re-exploration for postoperative bleeding after open-heart surgery in patients who present with an acute coronary syndrome. Circulation. 2002;106(suppl I):I-19–I-22
  7. Bijsterveld NR, Peters RJG, Murphy SA, et al. Recurrent cardiac ischemic events early after discontinuation of short-term heparin treatment in acute coronary syndromes (Results from the thrombolysis in myocardial infarction (TIMI) 11B and efficacy and safety of subcutaneous enoxaparin in non-Q-wave coronary events (ESSENCE) studies). J Am Coll Cardiol. 2003;42:2083–2089
  8. Bijsterveld NR, Moons AH, Meijers JCM, et al. Rebound thrombin generation after heparin therapy in unstable angina (A randomized comparison between unfractionated and low-molecular-weight heparin). J Am Coll Cardiol. 2002;39:811–817
  9. Pleym H, Videm V, Wahba A, et al. Heparin resistance and increased platelet activation in coronary surgery patients treated with enoxaparin preoperatively. Eur J Cardiothorac Surg. 2006;29:933–940
  10. Hett DA, Walker D, Pilkington SN, et al. Sonoclot analysis. Br J Anaesth. 1995;75:771–776
  11. Pleym A, Wahba A, Bjella L, et al. Sonoclot analysis in elderly compared with younger patients undergoing coronary surgery. Acta Anaesthesiol Scand. 2008;52:28–35
  12. Merlini PA, Bauer KA, Oltrona L, et al. Persistent activation of coagulation mechanism in unstable angina and myocardial infarction. Circulation. 1994;90:61–68
  13. Hoffmeister HM, Jur M, Wendel HP, et al. Alterations of coagulation and fibrinolytic and kallikrein-kinin systems in the acute and postacute phases in patients with unstable angina pectoris. Circulation. 1995;91:2520–2527
  14. Bjessmo S, Ivert T, Egberg N. Coagulation system activity before coronary artery bypass surgery for unstable angina. Scand Cardiovasc J. 2001;35:280–284
  15. Pleym H, Stenseth R, Wahba A, et al. Single-dose tranexamic acid reduces postoperative bleeding after coronary surgery in patients treated with aspirin until surgery. Anesth Analg. 2003;96:923–928

PII: S1053-0770(07)00408-9

doi: 10.1053/j.jvca.2007.12.024

Journal of Cardiothoracic and Vascular Anesthesia
Volume 22, Issue 5 , Pages 670-674 , October 2008

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