Journal of Cardiothoracic and Vascular Anesthesia
Volume 22, Issue 6 , Pages 832-839 , December 2008

The Role of Oral Coenzyme Q10 in Patients Undergoing Coronary Artery Bypass Graft Surgery

  • Neeti Makhija, MD

      Affiliations

    • Department of Cardiac Anaesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    • Corresponding Author InformationAddress reprint requests to Neeti Makhija, MD, 7th Floor, Department of Cardiac Anaesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    • ,
  • Chaitali Sendasgupta, MD, DNB, DM

      Affiliations

    • Department of Cardiac Anaesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    • ,
  • Usha Kiran, MD

      Affiliations

    • Department of Cardiac Anaesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    • ,
  • R. Lakshmy, PhD

      Affiliations

    • Department of Cardiac Biochemistry, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    • ,
  • Milind P. Hote, MS, MCh

      Affiliations

    • Department of Cardiothoracic and Vascular Surgery, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    • ,
  • Shiv K. Choudhary, MS, MCh

      Affiliations

    • Department of Cardiothoracic and Vascular Surgery, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    • ,
  • Balram Airan, MS, MCh

      Affiliations

    • Department of Cardiothoracic and Vascular Surgery, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    • ,
  • Ransi Abraham, MSc

      Affiliations

    • Department of Cardiac Biochemistry, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

References 

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  9. Matsushima T, Sueda T, Matsuura Y, et al. Protection by coenzyme Q10 of canine myocardial reperfusion injury after preservation. J Thorac Cardiovasc Surg. 1992;103:945–951
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  11. Sunamori M, Tanaka H, Maruyama T, et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovasc Drugs Ther. 1991;5(suppl 2):297–300
  12. Taggart DP, Jenkins M, Hooper J, et al. Effects of short-term supplementation with coenzyme Q10 on myocardial protection during cardiac operations. Ann Thorac Surg. 1996;61:829–833
  13. Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg. 1994;58:1427–1432
  14. Chen YF, Lin YT, Wu SC. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. J Thorac Cardiovasc Surg. 1994;107:242–247
  15. Rosenfeldt F, Marasco S, Lyon W, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac Cardiovasc Surg. 2005;129:25–32
  16. Judy WV, Stogsdill WW, Folkers K. Myocardial preservation by therapy with coenzyme Q10 during heart surgery. Clin Investig. 1993;71(suppl 8):S155–S161
  17. Miller NJ, Rice-Evans C, Davies MJ. A new method for measuring antioxidant activity. Biochem Soc Trans. 1993;21:95S
  18. Rice-Evans C, Miller N. Total antioxidant status in plasma and body fluids. Methods Enzymol. 1994;234:279–293
  19. Pepping J. Coenzyme Q10. Am J Health Syst Pharm. 1999;56:519–521
  20. Ferrante KL, Shefner J, Zhang H, et al. Tolerance of high dose (3,000 mg/day) of coenzyme Q10 in ALS. Neurology. 2005;65:1834–1836
  21. Manning A. Reperfusion-induced arrhythmias: The major determining factor. J Mol Cell Cardiol. 1986;18(suppl 4):49–53
  22. Shattock MJ, Matsuura H, Hearse DJ. Functional and electrophysiological effects of oxidant stress on isolated ventricular muscle: A role for oscillatory calcium release from sarcoplasmic reticulum in arrhythmogenesis?. Cardiovasc Res. 1991;25:645–651
  23. Kato T, Yoneda S, Kako T, et al. Reduction in blood viscosity by treatment with coenzyme Q10 in patients with ischemic heart disease. Int J Clin Pharmacol Ther Toxicol. 1990;28:123–126
  24. Eriksson JG, Forsen TJ, Mortensen SA, et al. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. Biofactors. 1999;9:315–318
  25. Henriksen JE, Andersen CB, Hother-Nielsen O, et al. Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with type 1 diabetes mellitus. Diabet Med. 1999;16:312–318
  26. Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: A controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002;56:1137–1142
  27. Hanioka T, Tanaka M, Ojima M, et al. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med. 1994;15(suppl):241–248

 Supported by an Institute Research Grant, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

PII: S1053-0770(08)00088-8

doi: 10.1053/j.jvca.2008.03.007

Journal of Cardiothoracic and Vascular Anesthesia
Volume 22, Issue 6 , Pages 832-839 , December 2008

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