Journal of Cardiothoracic and Vascular Anesthesia
Volume 23, Issue 1 , Pages 41-47 , February 2009

Methemoglobin Effects on Coagulation: A Dose-Response Study With HBOC-200 (Oxyglobin) in a Thrombelastogram Model

  • Mojgan Moallempour, MD

      Affiliations

    • Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • ,
  • Jonathan S. Jahr, MD

      Affiliations

    • Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • Corresponding Author InformationAddress reprint requests to Jonathan S. Jahr, MD, Department of Anesthesiology, David Geffen School of Medicine at UCLA, CHS 56-122, Box 951778, 650 Charles E. Young Drive South, Los Angeles, CA 90095
    • ,
  • Jennifer C. Lim

      Affiliations

    • Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • ,
  • David Weeks, PhD, MD

      Affiliations

    • Department of Anesthesiology, University of California, San Francisco, San Francisco, CA
    • ,
  • Anthony Butch, PhD

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
    • ,
  • Bernd Driessen, DVM, PhD

      Affiliations

    • Department of Clinical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA

References 

  1. TEG 5000 User's Manual. In: Niles, IL: Haemoscope Inc; 2005;p. 178
  2. Yeh LH, Alayash AI. Redox side reactions of haemoglobin and cell signaling mechanisms. J Int Med. 2003;258:518–526
  3. Essex DW, Li M. Redox modification of platelet glycoproteins. Current Drug Targets. 2006;7:1233–1241
  4. Sprung J, Kindscher JD, Wahr JA, et al. The use of Bovine Hemoglobin Glutamer-250 (Hemopure®) in surgical patients: Results of a muticenter, randomized, single-blinded trial. Anesth Analg. 2002;94:799–808
  5. Jahr JS, Weeks D, Desai P, et al. Does Oxyvita, a new generation hemoglobin-based oxygen carrier, or Oxyglobin acutely interfere with coagulation compared with normal saline or 6% Hetastarch? (An ex vivo thromboelastography preliminary study). J Cardiothorac Vasc Anesth. 2008;22:34–39
  6. Osgood SL, Jahr JS, Desai P, et al. Does methemoglobin from oxidized hemoglobin-based oxygen carrier (Hemoglobin Glutamer-200) interfere with lactate measurement (YSI 2700 SELECT™ Biochemistry Analyzer). Anesth Analg. 2005;100:437–439
  7. Iselin BM, Willimann PFX, Seifert BM, et al. Isolated reduction of haematocrit does not compromise in vitro blood coagulation. Br J Anaesth. 2001;87:246–249
  8. Jahr JS, Lurie F, Gosselin R, et al. Effects of Hemoglobin-250 (Bovine) (HBOC-201, Hemopure) on coagulation testing. Am J Ther. 2002;9:431–436
  9. James MF, Potgieter HE, Ellis P. The effect of Hemopure® on coagulation in clinically relevant concentrations. Anesth Analg. 2004;99:1593–1597

 J.S.J. was a principle investigator in a phase 2 and phase 3 study with Biopure. Veterinary product Oxyglobin was purchased at Veterinary Pharmacy for the purposes of this study.

PII: S1053-0770(08)00182-1

doi: 10.1053/j.jvca.2008.06.006

Journal of Cardiothoracic and Vascular Anesthesia
Volume 23, Issue 1 , Pages 41-47 , February 2009

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