Journal of Cardiothoracic and Vascular Anesthesia
Volume 22, Issue 5 , Pages 655-661 , October 2008

Can ROTEM Thromboelastometry Predict Postoperative Bleeding After Cardiac Surgery?

  • Simon J. Davidson, FIBMS

      Affiliations

    • Department of Haematology, Royal Bromptom Hospital, London, United Kingdom
    • Corresponding Author InformationAddress reprint requests to Simon J. Davidson, BSc, Department of Haematology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    • ,
  • Donovan McGrowder, PhD

      Affiliations

    • Department of Haematology, Royal Bromptom Hospital, London, United Kingdom
    • ,
  • Michael Roughton, MSc

      Affiliations

    • Department of Research and Development, Royal Bromptom Hospital, London, United Kingdom
    • ,
  • Andrea A. Kelleher, MD

      Affiliations

    • Department of Anaesthetics, Royal Brompton Hospital, London, United Kingdom

References 

  1. Murphy GJ, Reeves BC, Rogers CA, et al. Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation. 2007;116:2544–2552
  2. Despotis G, Joist J, Goodnough L. Monitoring of hemostasis in cardiac surgical patients: Impact of point-of-care testing on blood loss and transfusion outcomes. Clin Chem. 1997;43:1684–1696
  3. Moulton M, Cresswell I, Mackay M, et al. Re-exploration for bleeding is a risk factor for adverse outcome after cardiac operations. J Thorac Cardiovasc Surg. 1996;111:1037–1046
  4. Karkouti K, Wijeysundera D, Yau T, et al. The independent association of massive blood loss with mortality in cardiac surgery. Transfusion. 2004;44:1453–1462
  5. Luddington RJ. Thromboelastography/thromboelastometry. Clin Lab Haematol. 2005;27:81–90
  6. Spalding GJ, Hartrumpf M, Sierig T, et al. Cost reduction of perioperative coagulation management in cardiac surgery: Value of “bedside” thromboelastography (ROTEM). Eur J Cardiothorac Surg. 2007;31:1052–1057
  7. Hartert H. Blutgerninungstudien mit der thromboelastographic, einen neven untersuchingsver fahren. Klin Wochenschr. 1948;16:257–260
  8. Tuman KJ, Spiess BD, McCarthy RJ, et al. Effects of progressive blood loss on coagulation as measured by thromboelastography. Anesth Analg. 1987;66:856–863
  9. Paparella D, Bristler S, Buchanan M. Coagulation disorders of cardiopulmonary bypass: A review. Intensive Care Med. 2004;30:1873–1881
  10. Spiess BD, Gillies BS, Chandler W, et al. Changes in transfusion therapy and reexploration rate after institution of a blood management program in cardiac surgical patients. J Cardiothorac Vasc Anesth. 1995;9:168–173
  11. Shore-Lesserson L, Manspeizer HE, DePerio M, et al. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg. 1999;88:312–319
  12. Nuttall G, Oliver W, Santrach P, et al. Efficacy of a simple intraoperative transfusion algorythm for non-erythrocyte component utilisation after cardiopulmonary bypass. Anaesthesiology. 2001;94:773–781
  13. Lang TA, Bauters AB, Braun SLC, et al. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis. 2005;16:301–310
  14. Nielsen VG. A comparison of the Thrombelastograph and the ROTEM. Blood Coagul Fibrinolysis. 2007;18:247–252
  15. Cammerer U, Dietrich W, Rampf T, et al. The predictive value of modified computerised thromboelastography and platelet function analysis for postoperative blood loss in routine cardiac surgery. Anesth Analg. 2003;96:51–57
  16. Gallimore MJ, Jones DW, Wendel HP. A chromogenic substrate assay kit for factor XII: Evaluation and use for the measurement of factor XII levels in cardiopulmonary bypass patients. Thromb Res. 1999;94:103–109

 Supported by Sysmex UK Ltd and Pentapharm.

PII: S1053-0770(08)00214-0

doi: 10.1053/j.jvca.2008.07.002

Journal of Cardiothoracic and Vascular Anesthesia
Volume 22, Issue 5 , Pages 655-661 , October 2008

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