Journal of Cardiothoracic and Vascular Anesthesia
Volume 23, Issue 3 , Pages 312-315 , June 2009

Tranexamic Acid Reduces Blood Loss in Off-Pump Coronary Artery Bypass Surgery

  • Reza Jalaeian Taghaddomi, MD

      Affiliations

    • Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashad, Iran
    • Corresponding Author InformationAddress reprint requests to Reza Jalaeian Taghaddomi, MD, Department of Anesthesiology, Ghaem Hospital, Ahmad Abad Street, Mashhad, Iran
    • ,
  • Asadollah Mirzaee, MD

      Affiliations

    • Department of Cardiosurgery, Chaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
    • ,
  • Alireza Sharifian Attar, MD

      Affiliations

    • Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashad, Iran
    • ,
  • Abbas Shirdel, MD

      Affiliations

    • Department of Hematology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashad, Iran

References 

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  2. Cartier R, Brann S, Dagenais F, et al. Systematic off-pump coronary artery revascularization multivessel disease: Experience of three hundred cases. J Thorac Cardiovasc Surg. 2000;119:221–229
  3. Nader ND, Reich NT, Khadra WZ, et al. Blood product use in cardiac revascularization: comparison of on- and off-pump techniques. Ann Thorac Surg. 1999;68:1640–1643
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  9. Fergusson DA, Hebert PC, Mazer CD, et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med. 2008;358:2319–2331
  10. Casati V, Gerli Ch, Franco A, et al. Tranexamic acid in off-pump coronary surgery: A preliminary, randomized, double-blind, placebo-controlled study. Ann Thorac Surg. 2001;72:470–475
  11. Vanek T, Jares M, Fajt R, et al. Fibrinolytic inhibitors in off-pump coronary surgery: A prospective, randomized, double-blind TAP study. Eur J Cardiothorac. 2005;28:563–568
  12. Wei M, Jian K, Guo Z, et al. Tranexamic acid reduces postoperative bleeding in off-pump coronary artery bypass grafting. Scand Cardiovasc J. 2006;40:105–190
  13. Jares M, Vanek T, Straka Z, et al. Tranexamic acid reduces bleeding after off-pump coronary artery bypass grafting. J Cardiovasc Surg (Torino). 2003;44:205–208
  14. Casati V, Della Valle P, Benussi S, et al. Effects of tranexamic acid in postoperative bleeding and related hematological variables in coronary surgery: Comparison between on-pump and off-pump techniques. J Thorac Cardiovasc Surg. 2004;128:83–91
  15. van Dijk D, Nierich AP, Jansen EW, et al. Early outcome after off-pump versus on-pump coronary bypass surgery: Results from a randomized study. Circulation. 2001;104:1761–1766
  16. Ascione R, Lloyd CT, Underwood MJ, et al. Economic outcome of off-pump coronary artery bypass surgery: A prospective randomized study. Ann Thorac Surg. 1999;68:2237–2242
  17. Mangano DT, Tudor IC, Dietzel C Multicenter Study of Perioperative Ischemia Research Group, Ischemia Research and Education Foundation. The risk associated with aprotinin in cardiac surgery. N Engl J Med. 2006;354:353–365
  18. Mangano DT, Miao Y, Vuylsteke A, et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA. 2007;297:471–479
  19. Ruel MA, Wang F, Bouker ME, et al. Is tranexamic acid safe in patients undergoing coronary endarterectomy?. Ann Thorac Surg. 2001;71:1508–1511
  20. Kareski J, Djaiani G, Carroll J, et al. Tranexamic acid and early saphenous vein graft patency in conventional coronary artery bypass graft surgery: A prospective randomized controlled clinical trial. J Thorac Cardiovasc Surg. 2005;130:309–314
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  22. Biglioli P, Cannata A, Alamanni F, et al. Biological effects of off-pump vs. on-pump coronary artery surgery: Focus on inflammation, hemostasis and oxidative stress. Eur J Cardiothorac Surg. 2003;24:260–269
  23. Hekmat K, Zimmermann T, Kampe S, et al. Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: A prospective, randomized, double-blind trial. Curr Med Res Opin. 2004;20:121–126
  24. Smith PK, Muhlbaier LH. Aprotinin: Safe and effective only with the full dose regimen. Ann Thorac Surg. 1996;62:1575–1577
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  26. Lemmer JH, Dilling EW, Morton JR, et al. Aprotinin for primary coronary artery bypass grafting: A multicenter trial of three dose regimens. Ann Thorac Surg. 1996;62:1659–1667
  27. Alderman EL, Levy JH, Rich JB, et al. Analyses of coronary graft patency after aprotinin use: Results from the international multicenter aprotinin graft patency experience (IMAGE) trial. J Thorac Cardiovasc Surg. 1998;116:716–730

PII: S1053-0770(08)00299-1

doi: 10.1053/j.jvca.2008.09.018

Journal of Cardiothoracic and Vascular Anesthesia
Volume 23, Issue 3 , Pages 312-315 , June 2009

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