Journal of Cardiothoracic and Vascular Anesthesia
Volume 23, Issue 5 , Pages 639-645 , October 2009

The Effects of Sevoflurane on Systemic and Pulmonary Inflammatory Responses After Cardiopulmonary Bypass

  • Eun Jung Cho, MD, PhD

      Affiliations

    • Department of Anesthesiology and Pain Medicine, Incheon St Mary's Hospital, Catholic University of Korea, Medical College, Incheon, Korea
    • ,
  • Jong Hyun Yoon, MD

      Affiliations

    • Department of Anesthesiology and Pain Medicine, St Mary's Hospital, Catholic University of Korea, Medical College, Seoul, Korea
    • ,
  • Sung Jin Hong, MD, PhD

      Affiliations

    • Department of Anesthesiology and Pain Medicine, St Mary's Hospital, Catholic University of Korea, Medical College, Seoul, Korea
    • Corresponding Author InformationAddress reprint requests to Sung Jin Hong, MD, PhD, Department of Anesthesiology and Pain Medicine, Catholic University of Korea, Medical College, St Mary's Hospital, 62 Yoidodong, Yongdungpogu, Seoul 150-010, Korea
    • ,
  • Sun Hee Lee, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, St Mary's Hospital, Catholic University of Korea, Medical College, Seoul, Korea
    • ,
  • Sung Bo Sim, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, St Mary's Hospital, Catholic University of Korea, Medical College, Seoul, Korea

References 

  1. Larmann J, Theilmeier G. Inflammatory response to cardiac surgery: cardiopulmonary bypass versus non-cardiopulmonary bypass surgery. Best Prac Res Clin Anaesth. 2004;18:425–438
  2. Cameron D. Initiation of white cell activation during cardiopulmonary bypass: Cytokines and receptors. J Cardiovasc Pharmacol. 1996;27(suppl 1):S1–S5
  3. Massaudy P, Zahler S, Becker BF, et al. Significant leukocyte and platelet retention during pulmonary passage after declamping of the aorta in CABG patients. Eur J Med Res. 1999;4:178–182
  4. Massaudy P, Zahler S, Becker BF, et al. Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass. Chest. 2001;119:31–36
  5. Shafique T, Johnson RG, Dai HB, et al. Altered pulmonary microvascular reactivity after total cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1993;106:479–486
  6. Ng CSH, Wan S, Arifi AA, et al. Inflammatory response to pulmonary ischemia-reperfusion injury. Surg Today. 2006;36:205–214
  7. El-Azab SR, Rosseel PMJ, DeLange JJ, et al. Effect of sevoflurane on the ex vivo secretion of TNF-α during and after coronary artery bypass surgery. Eur J Anaesth. 2003;20:380–384
  8. Nader ND, Karamanoukian HL, Reedy RL, et al. Inclusion of sevoflurane in cardioplegia reduces neutrophil activity during cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2006;20:57–62
  9. El-Azab SR, Roseel PMJ, DeLange JJ, et al. Effect of VIMA with sevoflurane versus TIVA with propofol or midazolam-sufentanil on the cytokine response during CABG surgery. Eur J Anaesth. 2002;19:276–282
  10. Brix-Christensen V, Tonnesen E, Sorensen IJ, et al. Effects of anaesthesia based on high-versus-low dose opioids on cytokine and acute-phase protein responses in patients undergoing cardiac surgery. Acta Anaesth Scand. 1998;42:63–70
  11. Wan S, DeSmert JM, Barvais L, et al. Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1996;112:806–811
  12. Liebold A, Keyl C, Birnbaum DE. The heart produces but the lungs consume proinflammatory cytokines following cardiopulmonary bypass. Eur J Cardiovasc Surg. 1999;15:340–345
  13. Nader ND, Li CM, Khadra WZ, et al. Anesthetic myocardial protection with sevoflurane. J Cardiothorac Vasc Anesth. 2004;18:269–274
  14. Guarracino F, Landoni G, Tritapepe L, et al. Myocardial damages prevented by volatile anesthetics: A multicenter randomized controlled study. J Cardiothorac Vasc Anesth. 2006;20:477–483
  15. Landoni G, Biondi-Zoccai GL, Zangrillo A, et al. Desflurane and sevoflurane in cardiac surgery: A meta-analysis of randomized clinical trials. J Cardiothorac Vasc Anesth. 2007;21:502–511
  16. Tritapepe L, Landoni G, Guarracino F, et al. Cardiac protection by volatile anesthetics: A multicentre randomized controlled study in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Eur J Anaesth. 2007;24:323–331
  17. Suleiman MS, Zacharowski K, Angelini GD. Inflammatory response and cardioprotection during open-heart surgery: The importance of anaesthetics. Br J Pharmacol. 2008;153:21–33
  18. Rashid MA, William-Olsson G. Are leukocytosis and lipid peroxidation involved in ischemic or reperfusion injury in cardiac surgery?. Thorac Cardiovasc Surg. 1991;39:193–195
  19. Hall I, Smith MF, Rocker G. The systemic inflammatory response to cardiopulmonary bypass: Pathophysiological, therapeutic, and pharmacological consideration. Anesth Analg. 1997;85:766–782
  20. Abdelhadi RH, Gurm HS, VanWagoner DR, et al. Relation of an exaggerated rise in white blood cells after coronary bypass or cardiac valve surgery to development of atrial fibrillation postoperatively. Am J Cardiol. 2004;93:1176–1178
  21. Ascione R, Lloyd CT, Underwood MJ, et al. Inflammatory response after coronary revascularization with or without cardiopulmonary bypass. Ann Thorac Surg. 2000;69:1198–1204
  22. Zahler S, Massaudy P, Hartl H, et al. Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass. Cardiovasc Res. 1999;41:722–730
  23. Alcaraz AJ, Manzano L, Sancho L, et al. Different proinflammatory cytokine serum pattern in neonate patients undergoing open heart surgery (Relevance of IL-8). J Clin Immunol. 2005;25:238–245
  24. Kunkel SL, Standiford T, Kasahara K, et al. Interleukin-8(IL-8): The major neutrophil chemotactic factor in the lung. Exp Lung Res. 1991;17:17–23
  25. Takala RSK, Soukka HR, Salo MS, et al. Pulmonary inflammatory mediators after sevoflurane and thiopentone anaesthesia in pigs. Acta Anaesthesiolo Scand. 2004;48:40–45
  26. Kotani N, Takahashi S, Sessler DI, et al. Volatile anesthetics augment expression of proinflammatory cytokines in rat alveolar macrophages during mechanical ventilation. Anesthesiology. 1999;91:187–197
  27. Hung CJ, Liu FY, Shaiu YC, et al. Assessing transient pulmonary injury induced by volatile anesthetics by increased lung uptake of Technetium-99m hexamethylpropylene amine oxime. Lung. 2003;181:1–7
  28. Schilling T, Kozian A, Kretzschmar M, et al. Effects of propofol and desflurane anaesthesia on the alveolar inflammation response to one-lung ventilation. Br J Anaesth. 2007;99:368–375
  29. Giomarelli P, Scoletta S, Borelli E, et al. Myocardial and lung injury after cardiopulmonary bypass: Role of interleukin (IL)-10. Ann Thorac Surg. 2003;76:117–123
  30. Celik JB, Gormus N, Okesli S, et al. Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-α, IL-6, IL-8, IL-10. Perfusion. 2004;19:185–191
  31. Conzen PF, Fischer S, Detter C, et al. Sevoflurane provide greater protection of the myocardium than propofol in patients undergoing off-pump coronary artery bypass surgery. Anesthesiology. 2003;99:826–833
  32. Bein B, Renner J, Caliebe D, et al. Sevoflurane but not propofol preserves myocardial function during minimally invasive direct coronary artery bypass surgery. Anesth Analg. 2005;100:610–616

PII: S1053-0770(09)00028-7

doi: 10.1053/j.jvca.2009.01.025

Journal of Cardiothoracic and Vascular Anesthesia
Volume 23, Issue 5 , Pages 639-645 , October 2009

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