The authors performed serial measurements of BNP and troponin-I in cardiac allograft donors and recipients, determining the relationship between these biomarkers and established risk factors for and measures of early graft dysfunction. Postoperative BNP correlated moderately with allograft ischemic time (ρ = 0.52, p = 0.01), donor BNP (ρ = 0.45, p = 0.03), and donor troponin-I (ρ = 0.49, p = 0.01). Postoperative BNP was higher in patients with persistently elevated inotrope requirements and enabled the early identification of such patients. In contrast, there was no association between postoperative troponin-I and these same parameters.
Conclusions
Postoperative BNP is associated with preimplantation and clinical performance parameters related to allograft ischemia-reperfusion injury at the time of cardiac transplantation, providing preliminary evidence to support its potential use as an ischemia-reperfusion injury biomarker in this context.
⁎Department of Anesthesiology, Columbia-Presbyterian Medical Center, New York, NY
†Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Australia
‡Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Australia
Address reprint requests to David R. McIlroy, MD, MClin Epi, FANZCA, Department of Anesthesiology, Columbia-Presbyterian Medical Center, PH5-505, 622 West 168th Street, New York, NY, 10032
Supported by The Alfred Hospital, Department of Anaesthesia Research Fund.
ABSTRACT