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Abstract
Cephalosporin antibiotics are used prophylactically in cardiothoracic surgery to prevent
postoperative infection. In 30 patients undergoing primary elective coronary artery
bypass grafting, the whole blood coagulation system was prospectively evaluated before,
and 10 and 30 minutes after administration of 1 g of cephapirin (Cefadyl, Bristol
Laboratory, Evansville, IN). All patients had normal preoperative coagulation studies
and had not received anticoagulant or antiplatelet therapy within 7 days of surgery.
At 10 minutes after cephapirin administration, 23 of 30 patients had a significant
change in all phases of whole blood coagulation as monitored by thromboelastography
(TEG). Thirty minutes after cephapirin administration there was no statistical difference
compared with the baseline TEG. It is concluded that cephapirin can cause a significant
but transient change in the viscoelastic properties of blood. Coagulation parameters
of the TEG should be measured prior to cephapirin administration to prevent errors
in establishing baseline values prior to cardiopulmonary bypass.
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Article info
Footnotes
☆This is a US government work. There are no restrictions on its use. 1053-0770/93!0704-0008$00.00/0
Identification
Copyright
© 1993 Published by Elsevier Inc.
