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Case report| Volume 23, ISSUE 2, P203-205, April 2009

The Management of Severe Primary Graft Failure After Cardiac Transplantation

Published:March 17, 2008DOI:https://doi.org/10.1053/j.jvca.2007.12.010
The Management of Severe Primary Graft Failure After Cardiac Transplantation
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      PRIMARY GRAFT FAILURE in the early postoperative period after heart transplantation is a severe complication, potentially leading to multiorgan failure, presenting with a poor outcome. It seems to be the result of poor donor conditions, acute cellular and humoral rejection, and prolonged ischemia time.
      • Segovia J.
      • Pulpon L.A.
      • Sanmartin M.
      • et al.
      Primary graft failure in heart transplantation: A multivariate analysis.
      Transplant Proc. 1998; 30: 1932
      Therapeutic options are limited to pharmacologic support with catecholamines and phosphodiesterase inhibitors. Mechanical support with intra-aortic counterpulsation or extracorporeal membrane oxygenation (ECMO) may be necessary in severe cases of primary graft failure.
      • Segovia J.
      • Pulpon L.A.
      • Sanmartin M.
      • et al.
      Primary graft failure in heart transplantation: A multivariate analysis.
      Transplant Proc. 1998; 30: 1932
      , 
      • Fernandez A.L.
      • Herreros J.M.
      • Llorens R.
      • et al.
      Primary graft failure after heart transplantation Successful recovery with pneumatic biventricular assistance.
      Int J Artif Organs. 1996; 19: 307-310

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      Article info

      Publication history

      Published online: March 17, 2008

      Footnotes

      D. Hauer and A. Beiras-Fernandez contributed equally to this work.

      Identification

      DOI: https://doi.org/10.1053/j.jvca.2007.12.010

      Copyright

      © 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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