Objective
The purpose of this study was to compare urinary neutrophil gelatinase-associated
lipocalin (NGAL) levels in off-pump and on-pump coronary artery bypass graft (CABG)
surgery.
Design
A matched cohort study.
Setting
A tertiary university hospital.
Participants
Thirty adult patients undergoing CABG surgery without cardiopulmonary bypass (off-pump)
matched to 30 patients with on-pump CABG surgery by age, preoperative serum creatinine,
Parsonnet score, ejection fraction, body mass index, and number of coronary artery
grafts.
Interventions
None, observational.
Measurements and Main Results
Urinary NGAL, a novel, highly sensitive biomarker for renal injury, was measured before
and immediately after surgery and then 3, 18, and 24 hours later. There were no differences
in urinary NGAL at any time point between patients subjected to off-pump or on-pump
CABG surgery; the peak urinary NGAL in patients who underwent off-pump CABG surgery
was 94.7 ± 30.9 ng/mL compared with 122.7 ± 57.0 ng/mL in patients with on-pump CABG
surgery (p = 0.6). Peak serum creatinine and the incidence of acute kidney injury also were
not different between the groups.
Conclusions
Urinary NGAL was not different in patients undergoing off-pump and on-pump CABG surgery
despite a very good match between the groups with respect to pre- and intraoperative
risk factors.
Key Words
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Article info
Publication history
Published online: February 09, 2009
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
