Congenital factor V deficiency is an extremely rare abnormality and may be associated
with significant bleeding as a result of trauma or surgery. Perioperative management
primarily includes the administration of fresh frozen plasma to replace the deficient
clotting factor. Acute administration of multiple blood products is a risk factor
for transfusion-associated circulatory overload. Herein, the case of a 71-year-old
man with an ejection fraction of 13% and a history of congenital factor V deficiency
who was at risk for significant bleeding and transfusion-associated circulatory overload
who underwent successful complex extraction of a right atrial pacing lead is reported.
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Published online: February 12, 2021
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- Perioperative Management of Hereditary Factor V Deficiency: Timing of Plasma Administration is Critical in Maximizing Hemostatic Potency of Transfused Factor VJournal of Cardiothoracic and Vascular AnesthesiaVol. 36Issue 6
- PreviewWe read the case report regarding the periprocedural management of hereditary factor V (FV) deficiency by Fitzsimons et al. with great interest.1 The authors are congratulated for successfully managing a challenging situation in which multiple units of fresh frozen plasma (FFP) had to be transfused in an elderly patient with severely decreased left ventricular function. No purified FV concentrate is available currently for clinical use,2 and, thus, FFP administration is the only therapeutic option.
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