: Intravenous ibuprofen is used to control fever and pain. This study aimed to assess
the analgesic effects of the addition of intravenous ibuprofen to multimodal analgesia
regimen for pain management after pediatric cardiac surgery.
: A randomized, controlled, double-blinded, superiority study.
: University Hospital.
: 78 pediatric patients who underwent open cardiac surgery using midline sternotomy
incision were screened for eligibility, of whom 10 were excluded leaving 68 patients
(34 patients in the ibuprofen group and 34 patients in the control group) for final
: Patients were randomly allocated to either ibuprofen group in which the patient
received intravenous ibuprofen infusion, 10mg/kg/6 h for 24 h or the control group
in which the patient received a placebo 0.9% saline.
Measurements and main results
: The primary endpoint was the 24 h postoperative fentanyl consumption and the secondary
endpoints were postoperative modified objective pain score (MOPS) and the incidence
ibuprofen-related side effects including vomiting, epigastric pain, bleeding and renal
dysfunction. The mean (SD) total fentanyl consumption (μg/kg) during the first postoperative
24 h following extubation was significantly lower (<0.001) in the ibuprofen group
(3.5±1.3) than the control group (5.1±1.4). The median (IQR) postoperative modified
objective pain score (MOPS) was significantly lower (p<0.05) in the ibuprofen group
than the control group at 0 h, 2 h, 12 h, 16 h, 20 h and 24 h postoperatively. Ibuprofen
did not cause a significant increase in the incidence of bleeding, epigastric pain
and vomiting. Postoperative renal dysfunction was not reported in any patient.
: The addition of intravenous ibuprofen to multimodal analgesia regimen for pain management
after pediatric cardiac surgery improves the postoperative analgesia in terms of reduction
of opioid consumption and pain scores.