ClotPro® viscoelastometry evaluation in cardiac surgery with cardiopulmonary bypass

Published:November 24, 2022DOI:



      : The aim of this study was to assess the reproducibility of the new viscoelastic analyzer ClotPro® and compare the parameters this system produces with the ROTEM® delta system in patients undergoing cardiac surgery with cardiopumonary bypass (CPB).


      Prospective and observational study.


      University Hospital.


      Forty adult patients undergoing cardiac surgery with CPB.


      Correlations were calculated between ClotPro® and ROTEM® delta parameters.

      Measurements and Main Results

      ClotPro® showed a high reproducibility in most of the parameters of each test while ROTEM® delta, although showed a low coefficient of variation in the parameters related to clot firmness, showed a high variability in the coagulation times. Excellent correlations were observed in most of the parameters of each test between ROTEM® delta and ClotPro® (≥0.93). However, a moderate correlation was obtained between the clotting time (CT) of the EXTEM and the EX-test (0.54). The concordance of amplitudes at different times within each test was almost of 100% on both thromboelastometers. Regarding absolute differences in test results, most of the measurements showed significant differences (p < 0.0001) between both devices.


      : ClotPro® can be used as an alternative to ROTEM® delta to evaluate coagulation function in cardiac surgery, but specific reference ranges need to be established first.

      Key Words

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