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ClotPro® viscoelastometry evaluation in cardiac surgery with cardiopulmonary bypass

Published:November 24, 2022DOI:https://doi.org/10.1053/j.jvca.2022.11.022

      Abstract

      Objective

      : The aim of this study was to assess the reproducibility of the new viscoelastic analyzer ClotPro® and compare the parameters this system produces with the ROTEM® delta system in patients undergoing cardiac surgery with cardiopumonary bypass (CPB).

      Design

      Prospective and observational study.

      Setting

      University Hospital.

      Participants

      Forty adult patients undergoing cardiac surgery with CPB.

      Interventions

      Correlations were calculated between ClotPro® and ROTEM® delta parameters.

      Measurements and Main Results

      ClotPro® showed a high reproducibility in most of the parameters of each test while ROTEM® delta, although showed a low coefficient of variation in the parameters related to clot firmness, showed a high variability in the coagulation times. Excellent correlations were observed in most of the parameters of each test between ROTEM® delta and ClotPro® (≥0.93). However, a moderate correlation was obtained between the clotting time (CT) of the EXTEM and the EX-test (0.54). The concordance of amplitudes at different times within each test was almost of 100% on both thromboelastometers. Regarding absolute differences in test results, most of the measurements showed significant differences (p < 0.0001) between both devices.

      Conclusions

      : ClotPro® can be used as an alternative to ROTEM® delta to evaluate coagulation function in cardiac surgery, but specific reference ranges need to be established first.

      Key Words

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