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Subcellular compartmentalisation of cAMP in heart failure and inotropic pharmacology

Published:November 24, 2022DOI:https://doi.org/10.1053/j.jvca.2022.11.026

      Abstract

      Cyclic-AMP is a second messenger downstream of many G-protein coupled receptors including the β1-adrenoceptor which is the target of many clinically used inotropic agents. When the Gαs subunit of a heterotrimeric G-protein is activated, it causes a localised elevation of cAMP. The significance of the spatial distribution of the elevation in cAMP is increasingly recognised, as is disturbance of these microdomains in diseased states. Herein, the spatial compartmentalisation of inotropic signalling is explored including from internalised receptors.

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