CARDIOPULMONARY BYPASS (CPB) is known to induce a systemic proinflammatory state and
may contribute to postoperative organ dysfunction, primarily through complement activation
secondary to blood passing through an artificial extracorporeal circuit.
1
,
2
,
3
Ultrafiltration may minimize some of the impact of the CPB-induced systemic inflammatory
response.
4
Traditionally, ultrafiltration may be conventional (CUF) or modified (MUF). Conventional
ultrafiltration has been employed extensively during CPB, and involves hemoconcentration
of both the priming volume and patient's blood volume at any point during CPB.
5
,6
In the early 1990s, Naik et al. introduced the concept of MUF
7
,8
,9
in which the patient's blood volume is hemoconcentrated after separation from CPB.
10
Naik et al. postulated it may permit blood-free cardiac surgery.
11
Blood is typically removed from the arterial cannula and returned through the venous
cannula. Others employ a modified technique in which blood is removed from the right
atrium and infused into the aorta, potentially reducing concerns about cerebral shunting.
12
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Published online: January 12, 2023
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